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The effect of ticag...
The effect of ticagrelor on growth of small abdominal aortic aneurysms-a randomized controlled trial
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- Wanhainen, Anders (author)
- Uppsala universitet,Kärlkirurgi
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- Mani, Kevin, 1975- (author)
- Uppsala universitet,Kärlkirurgi
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- Kullberg, Joel, 1979- (author)
- Uppsala universitet,Radiologi,Antaros Medical
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- Svensjö, Sverker, 1968- (author)
- Uppsala universitet,Kärlkirurgi,Falun County Hospital
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- Bersztel, A. (author)
- Uppsala universitet,Kärlkirurgi,Västerås county hospital
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- Karlsson, Lars, 1959- (author)
- Uppsala universitet,Kärlkirurgi,Gävle County Hospital
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Holst, J. (author)
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Gottsater, A. (author)
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- Linne, A. (author)
- Karolinska Institutet
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- Gillgren, P. (author)
- Karolinska Institutet,Uppsala universitet,Kärlkirurgi,Mälarsjukhuset
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- Langenskiöld, Marcus, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Hultgren, R. (author)
- Karolinska Institutet
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- Roy, J. (author)
- Karolinska Institutet
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Gilgen, N. P. (author)
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- Ahlström, Håkan, 1953- (author)
- Uppsala universitet,Radiologi,Antaros Medical
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Lederle, F. A. (author)
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- Björck, Martin (author)
- Uppsala universitet,Kärlkirurgi
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(creator_code:org_t)
- 2019-05-28
- 2020
- English.
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In: Cardiovascular Research. - : Oxford University Press (OUP). - 0008-6363 .- 1755-3245. ; 116:2, s. 450-456
- Related links:
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Aims: To evaluate if ticagrelor, an effective platelet inhibitor without known non-responders, could inhibit growth of small abdominal aortic aneurysms (AAAs). Methods and results: In this multi-centre randomized controlled trial, double-blinded for ticagrelor and placebo, acetylic salicylic acid naive patients with AAA and with a maximum aortic diameter 35-49mm were included. The primary outcome was mean reduction in log-transformed AAA volume growth rate (%) measured with magnetic resonance imaging (MRI) at 12months compared with baseline. Secondary outcomes include AAA-diameter growth rate and intraluminal thrombus (ILT) volume enlargement rate. A total of 144 patients from eight Swedish centres were randomized (72 in each group). MRI AAA volume increase was 9.1% for the ticagrelor group and 7.5% for the placebo group (P=0.205) based on intention-to-treat analysis, and 8.5% vs. 7.4% in a per-protocol analysis (P=0.372). MRI diameter change was 2.5mm vs. 1.8mm (P=0.113), US diameter change 2.3mm vs. 2.2mm (P=0.778), and ILT volume change 12.9% vs. 10.4% (P=0.590). Conclusion: In this RCT, platelet inhibition with ticagrelor did not reduce growth of small AAAs. Whether the ILT has an important pathophysiological role for AAA growth cannot be determined based on this study due to the observed lack of thrombus modulating effect of ticagrelor.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Abdominal aortic aneurysm
- Growth inhibitor
- Intraluminal thrombus
- Ticagrelor
- Anti-platelet treatment
- Randomized controlled trial
- Aortic
- volume
- Aortic diameter
- bleeding
- acute coronary syndromes
- intraluminal thrombus
- mural thrombus
- double-blind
- steady flow
- volume
- clopidogrel
- Cardiovascular System & Cardiology
- Abdominal aortic aneurysm
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Wanhainen, Ander ...
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Mani, Kevin, 197 ...
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Kullberg, Joel, ...
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Svensjö, Sverker ...
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Bersztel, A.
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Karlsson, Lars, ...
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show more...
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Holst, J.
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Gottsater, A.
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Linne, A.
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Gillgren, P.
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Langenskiöld, Ma ...
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Hultgren, R.
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Roy, J.
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Gilgen, N. P.
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Ahlström, Håkan, ...
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Lederle, F. A.
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Björck, Martin
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Cardiovascular R ...
- By the university
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University of Gothenburg
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Uppsala University
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Karolinska Institutet